Researching Under-Represented Groups: How to Empower Students through Targeted Learning Development Support

The Scottish Government has tasked Higher Education Institutions with improving the recruitment, retention and progression of students who are classified as living within the lowest deprivation quintile according to the Scottish Index of Multiple Deprivati on (Scottish Government, 2012). The Scottish Funding Council allocates ringfenced funding for this purpose and negotiates specific outcome agreements with each institution to measure and evaluate success. As an initiative funded in this way, the School of Health and Life Science’s Learning Development Centre (LDC) at Glasgow Caledonian University is required to support students from low participation postcodes. The LDC provides enhancement - led, learning support to all students in the School through a blend of timetabled, in - programme teaching, workshops and one to one appointments. Support for, and monitoring of, those identified as belonging to the ‘multiple deprivations’ category (MD20s), however, is becoming an increasing priority. Whilst clearly a desira ble aim in terms of social justice and widening participation, it is less obvious how best to target and measure support. The risks of stigmatising, alienating or even creating dependency amongst what is surely a heterogeneous group are manifold. This pape r will report on research conducted by the LDC members that attempted to better understand the diverse group of ‘MD20 students’ who attend, or potentially attend programmes within the School. The aim of the project was to provide an evidence - base on which further support activities could be built. Cognisant of the diversity of the group in question and the risk of labelling or categorising students, the project employed a narrative or biographical approach which aimed to capture and explore the individual l ife histories of students (Field, Merrill & West, 2012). In particular, it investigated the paths their lives had taken to lead them to study at university, how they felt about the MD20 focus and what kind of support, if any, would empower them to succeed in their studies. Alongside in - depth, qualitative exploration of the issues, academic performance and baseline demographic data were collected to gather as full a picture as possible of the group in question

A Guide to Global Population Projections

Interdisciplinary studies that draw on long-term, global population projections often make limited use of projection results, due at least in part to the historically opaque nature of the projection process. We present a guide to such projections aimed at researchers and educators who would benefit from putting them to greater use. Drawing on new practices and new thinking on uncertainty, methodology, and the likely future courses of fertility and life expectancy, we discuss who makes projections and how, and the key assumptions upon which they are based. We also compare methodology and recent results from prominent institutions and provide a guide to other sources of demographic information, pointers to projection results, and an entry point to key literature in the field.forecasting, population projections, projection methodology, uncertainty

Cysteamine as a future intervention in cystic fibrosis against current and emerging pathogens : a patient-based ex vivo study confirming its antimicrobial and mucoactive potential in sputum

Date of Acceptance: 07/08/2015 Acknowledgement This study was funded by Scottish Enterprise Encompass Kick Start Award KSB001.Peer reviewedPublisher PD

Digital transformation of peatland eco-innovations (‘Paludiculture’): Enabling a paradigm shift towards the real-time sustainable production of ‘green-friendly’ products and services

The world is heading in the wrong direction on carbon emissions where we are not on track to limit global warming to 1.5 degrees C; Ireland is among the countries where overall emissions have continued to rise. The development of wettable peatland products and services (termed 'Paludiculture') present significant opportunities for enabling a transition away from peat-harvesting (fossil fuels) to developing 'green' eco-innovations. However, this must be balanced with sustainable carbon sequestration and environmental protection. This complex transition from 'brown to green' must be met in real time by enabling digital technologies across the full value chain. This will potentially necessitate creation of new green-business models with the potential to support disruptive innovation. This timely paper describes digital transformation of paludiculture-based eco-innovation that will potentially lead to a paradigm shift towards using smart digital technologies to address efficiency of products and services along with future-proofing for climate change. Digital transform of paludiculture also aligns with the 'Industry 5.0 -a human-centric solution'. However, companies supporting peatland innovation may lack necessary standards, data-sharing or capabilities that can also affect viable business model propositions that can jeopardize economic, political and social sustainability. Digital solutions may reduce costs, increase productivity, improve produce develop, and achieve faster time to market for paludiculture. Digitisation also enables information systems to be open, interoperable, and user-friendly. This constitutes the first study to describe the digital transformation of paludiculture, both vertically and horizontally, in order to inform sustainability that includes process automation via AI, machine learning, IoT-Cloud informed sensors and robotics, virtual and augmented reality, and blockchain for cyber-physical systems. Thus, the aim of this paper is to describe the applicability of digital transformation to actualize the benefits and opportunities of paludiculture activities and enterprises in the Irish midlands with a global orientation.info:eu-repo/semantics/publishedVersio

Influence of inflammatory polyarthritis on quantitative heel ultrasound measurements.

BACKGROUND: There are few data concerning the impact of inflammatory polyarthritis (IP) on quantitative heel ultrasound (QUS) measurements. The aims of this analysis were i) to determine the influence of IP on QUS measurements at the heel and, ii) among those with IP to determine the influence of disease related factors on these measurements. METHODS: Men and women aged 16 years and over with recent onset IP were recruited to the Norfolk Arthritis Register (NOAR). Individuals with an onset of joint symptoms between 1989 and 1999 were included in this analysis. At the baseline visit subjects underwent a standardised interview and clinical examination with blood taken for rheumatoid factor. A population-based prospective study of chronic disease (EPIC-Norfolk) independently recruited men and women aged 40 to 79 years from the same geographic area between 1993 and 1997. At a follow up assessment between 1998 and 2000 subjects in EPIC-Norfolk were invited to have quantitative ultrasound measurements of the heel (CUBA-Clinical) performed. We compared speed of sound (SOS) and broadband ultrasound attenuation (BUA), in those subjects recruited to NOAR who had ultrasound measurements performed (as part of EPIC-Norfolk) subsequent to the onset of joint symptoms with a group of age and sex matched non-IP controls who had participated in EPIC-Norfolk. Fixed effect linear regression was used to explore the influence of IP on the heel ultrasound parameters (SOS and BUA) so the association could be quantified as the mean difference in BUA and SOS between cases and controls. In those with IP, linear regression was used to examine the association between these parameters and disease related factors. RESULTS: 139 men and women with IP and 278 controls (mean age 63.2 years) were studied. Among those with IP, mean BUA was 76.3 dB/MHz and SOS 1621.8 m/s. SOS was lower among those with IP than the controls (difference = -10.0; 95% confidence interval (CI) -17.4, -2.6) though BUA was similar (difference = -1.2; 95% CI -4.5, +2.1). The difference in SOS persisted after adjusting for body mass index and steroid use. Among those with IP, disease activity as determined by the number of swollen joints at baseline, was associated with a lower SOS. In addition SOS was lower in the subgroup that satisfied the 1987 ACR criteria. By contrast, disease duration, steroid use and HAQ score were not associated with either BUA or SOS. CONCLUSIONS: In this general population derived cohort of individuals with inflammatory polyarthritis there is evidence from ultrasound of a potentially adverse effect on the skeleton. The effect appears more marked in those with active disease.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose

Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection. Objectives To investigate whether elevation of basolateral/blood glucose concentration promotes airway Staphylococcus aureus growth and whether pretreatment with the antidiabetic drug metformin affects this relationship. Methods Human airway epithelial cells grown at air–liquid interface (±18 h pre-treatment, 30 μM–1 mM metformin) were inoculated with 5×105 colony-forming units (CFU)/cm2 S aureus 8325-4 or JE2 or Pseudomonas aeruginosa PA01 on the apical surface and incubated for 7 h. Wild-type C57BL/6 or db/db (leptin receptor-deficient) mice, 6–10 weeks old, were treated with intraperitoneal phosphate-buffered saline or 40 mg/kg metformin for 2 days before intranasal inoculation with 1×107 CFU S aureus. Mice were culled 24 h after infection and bronchoalveolar lavage fluid collected. Results Apical S aureus growth increased with basolateral glucose concentration in an in vitro airway epithelia–bacteria co-culture model. S aureus reduced transepithelial electrical resistance (RT) and increased paracellular glucose flux. Metformin inhibited the glucose-induced growth of S aureus, increased RT and decreased glucose flux. Diabetic (db/db) mice infected with S aureus exhibited a higher bacterial load in their airways than control mice after 2 days and metformin treatment reversed this effect. Metformin did not decrease blood glucose but reduced paracellular flux across ex vivo murine tracheas. Conclusions Hyperglycaemia promotes respiratory S aureus infection, and metformin modifies glucose flux across the airway epithelium to limit hyperglycaemia-induced bacterial growth. Metformin might, therefore, be of additional benefit in the prevention and treatment of respiratory infection